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A Call to Consider Genetic Testing for Young Athletes

By: Frankie Jupiter Email
By: Frankie Jupiter Email

June 4, 2012

Should high school athletes and prospective military personnel be genetically tested to determine if they are at increased risk for dementia caused by repeated head injuries? The dean of the University of Virginia School of Medicine and the director of Mount Sinai’s NFL Neurological Program are asking that question – and offering recommendations to clarify the ethical issues that accompany it.

"What we're asking researchers to do is consider adding head trauma and the nature of it to their list on things to follow so that we see if there are real different risks as they grow up," said Dr. Steven T. DeKosky, UVa. School of Medicine Dean.

The long-term effects of traumatic brain injury [TBI] have been spotlighted by the high-profile suicides of former NFL players Junior Seau and Dave Duerson. Increasing evidence suggests that repeated head injuries, whether from sports or the battlefield, can lead to dementia in later life. But genetics play an important role as well, potentially increasing the risk for late-life dementia more than 10 fold.

That has prompted Dr. DeKosky, and Sam Gandy, MD, the chair in Alzheimer’s research at the Mount Sinai School of Medicine, to examine whether genetic testing could help avert dementia and reduce the costs of dementia care – a figure estimated to top $1 trillion annually by 2050.

Key information missing:

In an editorial in the journal Science Translational Medicine, DeKosky and Gandy note there is a lack of vital information on which to base a decision on the value of such genetic testing. They conducted an informal poll of experts in Alzheimer’s disease, TBI and related areas, and they found a significant majority of the 45 respondents agreed that it was premature to introduce genetic testing into schools or the military. What is needed, DeKosky and Gandy conclude, is additional information to evaluate the usefulness of such testing.

Finding solutions:

One approach to collecting the necessary data, they suggest, would be to set up a network of research centers. This would allow for the collection of data from an array of subjects, including high-risk adolescents exposed to brain injuries through sports. The information could then be used to create predictive mathematical models.

DeKosky and Gandy also suggest that valuable data could be drawn from studies now being assembled, such as the National Institute of Child Health and Development Vanguard Study, which plans to track major life events of 100,000 children until their 21st birthdays.

Ethical and psychological issues:

DeKosky and Gandy note that there are both ethical and psychological complexities to the question of genetic testing. “There is a very real concern about the effect of genotype information on family members and on personal employability and insurability,” they write. “In addition, recruiting high school-age subjects for … genotyping and follow-up could be controversial as parental informed consent would be required, necessitating pre-test genetic counseling for adolescents and their parents.”

Steve Heon, the Athletic Director at Western Albemarle High School, wants to do anything he can to ensure the safety of his players.

“If the research shows that there is a means to determine whether someone is more susceptible to a head injury, that’s certainly information that we would want to know,” said Heon.

Despite such concerns, DeKosky and Gandy conclude that considering genetic testing for high school athletes and the military “is, without a doubt, a worthwhile challenge.”


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