With second-leading scorer Joe Harris limited by a protective cast on his left hand, No. 22 Virginia struggled to put points on the board Tuesday night at Clemson.
The Cavaliers had their second-lowest scoring output of the season in a 48-45 loss to the Tigers. With the loss, Virginia drops to 19-6 on the season, 6-5 in the ACC.
It marks the first time the Cavaliers have lost back-to-back games this season.
Harris, who broke a bone in his non-shooting hand in Saturday's loss at North Carolina, came off the bench for the first time this season. He scored two points (on 1-5 shooting) in 21 minutes of play.
Freshman Malcolm Brogdon made his first college start in place of Harris. Brogdon had nine points and three assists, but also turned the ball over a team-high four times.
Harris, Jontel Evans, and Akil Mitchell each had three turnovers for the Cavaliers. Virginia had 18 giveaways as a team.
Evans matched his career high with 17 points to lead the Cavaliers. Senior Mike Scott added 13 points and eight rebounds. Virginia shot 50 percent from the field as a team, but was just 3-16 on three-pointers, and Evans made the team's only free throw attempt of the night.
Guards Andre Young and Tanner Smith each had 13 points to lead the Tigers, who improved to 13-12 on the season (5-6 in the ACC).